Our rescue experiments showed a significant decrease in the ability to maintain proper somatic muscle and gut morphology upon deletion of the MIB-specific but not the HERC2 domains. Although we can detect robust expression of the MIB domain-deleted constructs (with ectopic expression levels at least as high as that of full-length Mib2), it is possible that folding or cellular distribution of the protein variants could be different. However, given the modular nature of substrate recognition as discussed above, we propose that the HERC2/ZZ/HERC2 and MIB domains of Drosophila Mib2 also act independently to recognize distinct epitopes on different molecules in order to execute multiple functions. Overall our data suggest that at least one of the MIB domains together with the ankyrin repeats is essential for functions needed to stabilize the embryonic musculature, whereas the HERC2 domains, like the RING fingers, could be connected to a subset of ubiquitination-dependent Mib2 functions that do not affect muscle integrity in the embryo. So far, targets that are directly ubiquitinated by Mib2 have not yet been identified, although a couple of candidates can be predicted based on indirect evidence. One candidate that was proposed in the context of myoblast fusion is the Gli-like transcription factor Lame duck (Lmd). Ubiquitinated Lmd is specifically expressed in fusion-competent myoblasts and appears to be degraded in a mib2-dependent manner in somatic and visceral muscles after myoblast fusion [18, 45]. In mib2 mutant embryos, Lmd appears to be ectopically stabilized in maturing myotubes after myoblast fusion where it might interfere with ongoing fusion or fiber differentiation processes [18, 45]. However, in contrast to the postulated structural functions of Mib2 that are mediated via the ankryrin and MIB domains, the presumed E3 ubiquitin ligase-dependent activities of Mib2 appear to contribute relatively little to its major function in maintaining muscle integrity during late embryogenesis [17, 18].
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Sorry to go off topic here, but @windracer I do the same thing. My FreeNAS box runs piwigo in a jail, and I just have a 'folder sync' app on my phone to copy my photos/movies to my NAS. I haven't messed with Piwigo beyond making creation dates in the db for each mp4 (the sync does not add it, I use a ridicious 3 variant regex to get it)I need to add to the cron to sync the pics and make thumbnails, just need to get around to digging through the code to reverse engineer it.Although I really like plg's VideoJS plugin, need to automate that too.Soon I am going to re-encode my phone videos, they are too big for any type of streaming. I will probably make another table and move the originals elsewehre.
this"1- don't use a GET/POST or anything that the user can manipulate, directly in an url, for safety reasons ( check XSS)"so you are saying the $_POST can have bad data? I first believed you have refereed to $_FILES can contain bad data (that was and still is my main concern).to be sincere i still don't fully understand how XSS works. i'm still a noob in programing.so the computer/browser of the Piwigo admin is hacked and a injected javascript can access cookie credentials and bypass this verification "check_status(ACCESS_ADMINISTRATOR);" from my plugin admin.phpif can bypass that verification then he can make a POST request with bad data that can compromise the Piwigo website itself?that is what are you saying?i can add pattern verification to POST data (check_input_parameter...) before execute, is a good idea.
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